Pathogenesis of esophageal squamous cell carcinoma with lymphoid stroma.
Hepatogastroenterology
; 48(38): 458-61, 2001.
Article
in En
| MEDLINE
| ID: mdl-11379332
ABSTRACT
BACKGROUND/AIMS:
Lymphocyte infiltration in esophageal cancer, especially when beneath intraepithelial carcinoma, is frequently seen. However, cases of esophageal cancer with a dense stromal infiltration of lymphocytes are rare and the pathogenesis of such cases has yet to be clearly demonstrated. The objective of this study is to clarify its pathogenesis.METHODOLOGY:
Four cases of esophageal squamous cell carcinoma with lymphoid stroma were investigated by immunohistochemical staining for the detection of Epstein-Barr virus, human papillomavirus, human leukocyte antigen-DR, as well as T and B cells in cancer tissue.RESULTS:
In these four cases, neither positive staining of Epstein-Barr virus nor human papillomavirus infection was detected. On the other hand, the expression of human leukocyte antigen-DR antigen was evident in all cases with dense T-cell infiltration in the tumor tissue and moderate B-cell infiltration around the tumor.CONCLUSIONS:
The expression of human leukocyte antigen-DR antigen without Epstein-Barr virus or human papillomavirus infection could thus be one possible pathogenesis of patients demonstrating esophageal squamous cell carcinoma with a lymphoid stroma.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Esophageal Neoplasms
/
Lymphocytes
/
Carcinoma, Squamous Cell
Type of study:
Etiology_studies
/
Observational_studies
Limits:
Aged
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Hepatogastroenterology
Year:
2001
Document type:
Article
Affiliation country:
Japan