Prevention of polymerization of M and Z alpha1-Antitrypsin (alpha1-AT) with trimethylamine N-oxide. Implications for the treatment of alpha1-at deficiency.

Devlin, G L; Parfrey, H; Tew, D J; Lomas, D A; Bottomley, S P

Devlin, G L; Parfrey, H; Tew, D J; Lomas, D A; Bottomley, S P.

Affiliation

Devlin GL; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia.

Am J Respir Cell Mol Biol ; 24(6): 727-32, 2001 Jun.

Article in En | MEDLINE | ID: mdl-11415938

Subject(s)

Methylamines/pharmacology; alpha 1-Antitrypsin Deficiency/drug therapy; alpha 1-Antitrypsin/drug effects; Homozygote; Humans; Protein Conformation/drug effects; Protein Denaturation/drug effects; Protein Folding; alpha 1-Antitrypsin Deficiency/genetics

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Collection: 01-internacional Database: MEDLINE Main subject: Alpha 1-Antitrypsin / Alpha 1-Antitrypsin Deficiency / Methylamines Limits: Humans Language: En Journal: Am J Respir Cell Mol Biol Journal subject: BIOLOGIA MOLECULAR Year: 2001 Document type: Article Affiliation country: Australia Country of publication: United States

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