T cell activation induces direct binding of the Crk adapter protein to the regulatory subunit of phosphatidylinositol 3-kinase (p85) via a complex mechanism involving the Cbl protein.

Gelkop, S; Babichev, Y; Isakov, N

Gelkop, S; Babichev, Y; Isakov, N.

Affiliation

Gelkop S; Department of Microbiology and Immunology, Faculty of Health Sciences, and the Cancer Research Center, Ben Gurion University of the Negev, Beer Sheva 84105, Israel.

J Biol Chem ; 276(39): 36174-82, 2001 Sep 28.

Article in En | MEDLINE | ID: mdl-11418612

Subject(s)

Lymphocyte Activation; Phosphatidylinositol 3-Kinases/metabolism; Proto-Oncogene Proteins/metabolism; T-Lymphocytes/enzymology; Ubiquitin-Protein Ligases; Blotting, Western; Cell Line; Cytosol/metabolism; Glutathione Transferase/metabolism; Humans; Immunoblotting; Jurkat Cells; Models, Biological; Phosphatidylinositol 3-Kinases/chemistry; Phosphorylation; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Proto-Oncogene Proteins/chemistry; Proto-Oncogene Proteins c-cbl; Proto-Oncogene Proteins c-crk; Recombinant Fusion Proteins/metabolism; Time Factors; Tyrosine/metabolism; src Homology Domains

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Collection: 01-internacional Database: MEDLINE Main subject: Lymphocyte Activation / T-Lymphocytes / Proto-Oncogene Proteins / Phosphatidylinositol 3-Kinases / Ubiquitin-Protein Ligases Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Biol Chem Year: 2001 Document type: Article Affiliation country: Israel Country of publication: United States

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