Total serum IgE and outcome in infants with recurrent wheezing.
Arch Dis Child
; 85(1): 23-5, 2001 Jul.
Article
in En
| MEDLINE
| ID: mdl-11420191
ABSTRACT
OBJECTIVE:
To investigate the relation between total serum IgE at 0.5-3 and 3-6 years, and the risk of allergic sensitisation and persistent wheezing up to 8 years of age.METHODS:
Prospective follow up study of 45 infants with highly recurrent wheezing, no allergic symptoms, and negative skin tests.RESULTS:
In the last follow up year, 15 children still suffered from wheezing. Five wheeze-free and four episodically wheezing children had become sensitised. No association was found between early (0.5-3 years) IgE z scores and the recurrence of wheezing during follow up, or atopic sensitisation. IgE z scores at 3-6 years were significantly higher in children with positive skin tests (p = 0.013), but were still not associated with recurrence of wheezing.CONCLUSIONS:
In subjects with frequent early wheezing and no signs of atopy, early total serum IgE measurements are not predictive of outcome.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Asthma
/
Immunoglobulin E
/
Respiratory Sounds
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Language:
En
Journal:
Arch Dis Child
Year:
2001
Document type:
Article
Affiliation country:
Italy