Phosphoinositide-3 kinase-PKB/Akt pathway activation is involved in fibroblast Rat-1 transformation by human T-cell leukemia virus type I tax.

Liu, Y; Wang, Y; Yamakuchi, M; Masuda, S; Tokioka, T; Yamaoka, S; Maruyama, I; Kitajima, I

Liu, Y; Wang, Y; Yamakuchi, M; Masuda, S; Tokioka, T; Yamaoka, S; Maruyama, I; Kitajima, I.

Affiliation

Liu Y; Department of Laboratory and Molecular Medicine, Faculty of Medicine, Kagoshima University, 8-35-1 Sakuragaka, Kagoshima, 890-8520, Japan.

Oncogene ; 20(20): 2514-26, 2001 May 03.

Article in En | MEDLINE | ID: mdl-11420661

Subject(s)

Cell Transformation, Viral/physiology; Gene Products, tax/physiology; Phosphatidylinositol 3-Kinases/physiology; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins/physiology; Signal Transduction/physiology; Androstadienes/pharmacology; Animals; Cell Line; Cell Transformation, Viral/drug effects; Chromatography, High Pressure Liquid; Enzyme Activation; Enzyme Inhibitors/pharmacology; Fibroblasts/enzymology; Fibroblasts/pathology; Fibroblasts/physiology; Gene Products, tax/genetics; Human T-lymphotropic virus 1; Humans; NF-kappa B/antagonists & inhibitors; Phosphatidylinositol 3-Kinases/metabolism; Phosphatidylinositol Phosphates/metabolism; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins/metabolism; Proto-Oncogene Proteins c-akt; Rats; Transfection; Wortmannin

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Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Cell Transformation, Viral / Gene Products, tax / Proto-Oncogene Proteins / Protein Serine-Threonine Kinases / Phosphatidylinositol 3-Kinases Limits: Animals / Humans Language: En Journal: Oncogene Journal subject: BIOLOGIA MOLECULAR / NEOPLASIAS Year: 2001 Document type: Article Affiliation country: Japan Country of publication: United kingdom

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