ICOS costimulation: It's not just for TH2 cells anymore.

Sperling, A I; Bluestone, J A

Sperling, A I; Bluestone, J A.

Affiliation

Sperling AI; Section of Pulmonary and Critical Care Medicine, Department of Medicine, and the Committee on Immunology, University of Chicago, Chicago, IL 60637, USA. asperlin@medicine.bsd.uchicago.edu

Nat Immunol ; 2(7): 573-4, 2001 Jul.

Article in En | MEDLINE | ID: mdl-11429535

ABSTRACT

ABSTRACT

A current paradigm has ICOS participating in TH2 costimulation. New data indicates ICOS regulates not only TH2 cells, but also TH1s.

Subject(s)

Antigens, Differentiation, T-Lymphocyte/immunology; Immunoconjugates; Signal Transduction/immunology; Th1 Cells/immunology; Th2 Cells/immunology; Abatacept; Animals; Antigens, CD; Antigens, Differentiation/immunology; CD40 Ligand/immunology; CTLA-4 Antigen; Cytokines/immunology; DNA-Binding Proteins/immunology; GATA3 Transcription Factor; Heart Transplantation/immunology; Inducible T-Cell Co-Stimulator Protein; Lymphocyte Activation/immunology; Proto-Oncogene Proteins/immunology; Proto-Oncogene Proteins c-maf; Trans-Activators/immunology; Transplantation, Homologous/immunology

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Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Antigens, Differentiation, T-Lymphocyte / Th2 Cells / Th1 Cells / Immunoconjugates Limits: Animals Language: En Journal: Nat Immunol Journal subject: ALERGIA E IMUNOLOGIA Year: 2001 Document type: Article Affiliation country: United States

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