Mouse model for thoracic congenital scoliosis.
J Pediatr Orthop
; 21(4): 537-40, 2001.
Article
in En
| MEDLINE
| ID: mdl-11433171
ABSTRACT
SUMMARY:
This study sought to produce a dose-response curve for acute and chronic maternal carbon monoxide (CO) exposure versus vertebral anomalies in mouse offspring and to determine the critical day of exposure. In Part I, pregnant CD-1 mice were exposed to an acute dose of CO at 9 days of gestation. A positive dose-response relationship of acute maternal CO exposure and vertebral anomalies in the offspring was produced. In Part II, pregnant females were exposed to chronic CO for the first 11 days of gestation. Chronic exposure to CO did not produce significant vertebral anomalies. In Part III, pregnant females were exposed to an acute dose of 600 ppm of CO at gestation day 8, 9, or 10. Day 9 in this mouse breed is the critical day for maternal exposure to CO. The detected anomalies were predominately in the thoracic spine.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Scoliosis
/
Thoracic Vertebrae
/
Carbon Monoxide Poisoning
/
Maternal Exposure
/
Disease Models, Animal
Type of study:
Diagnostic_studies
/
Prognostic_studies
Limits:
Animals
/
Pregnancy
Language:
En
Journal:
J Pediatr Orthop
Year:
2001
Document type:
Article
Affiliation country:
United States