Hepatic distribution of a phosphorothioate oligodeoxynucleotide within rodents following intravenous administration.

Graham, M J; Crooke, S T; Lemonidis, K M; Gaus, H J; Templin, M V; Crooke, R M

Graham, M J; Crooke, S T; Lemonidis, K M; Gaus, H J; Templin, M V; Crooke, R M.

Affiliation

Graham MJ; ISIS Pharmaceuticals, Inc., Carlsbad Research Center, 1896 Rutherford Rd., Carlsbad, CA 92008, USA. mgraham@isisph.com

Biochem Pharmacol ; 62(3): 297-306, 2001 Aug 01.

Article in En | MEDLINE | ID: mdl-11434902

Subject(s)

Liver/metabolism; Oligodeoxyribonucleotides, Antisense/pharmacokinetics; Thionucleotides/pharmacokinetics; Animals; Antiviral Agents/metabolism; Antiviral Agents/pharmacokinetics; Dose-Response Relationship, Drug; Injections, Intravenous; Kinetics; Liver/drug effects; Male; Oligodeoxyribonucleotides, Antisense/metabolism; Rats; Rats, Sprague-Dawley; Subcellular Fractions/metabolism; Thionucleotides/metabolism; Time Factors; Tissue Distribution

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Collection: 01-internacional Database: MEDLINE Main subject: Thionucleotides / Oligodeoxyribonucleotides, Antisense / Liver Type of study: Prognostic_studies Limits: Animals Language: En Journal: Biochem Pharmacol Year: 2001 Document type: Article Affiliation country: United States Country of publication: United kingdom

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