Kinetic studies of guinea pig liver transglutaminase reveal a general-base-catalyzed deacylation mechanism.

Leblanc, A; Gravel, C; Labelle, J; Keillor, J W

Leblanc, A; Gravel, C; Labelle, J; Keillor, J W.

Affiliation

Leblanc A; Département de Chimie, Université de Montréal, C.P. 6128, Succursale centre-ville, Montréal, Québec, Canada H3C 3J7.

Biochemistry ; 40(28): 8335-42, 2001 Jul 27.

Article in En | MEDLINE | ID: mdl-11444980

Subject(s)

Liver/enzymology; Transglutaminases/chemistry; Transglutaminases/metabolism; Acylation; Amines/chemistry; Animals; Binding Sites; Catalysis; Chromogenic Compounds/chemical synthesis; Deuterium/chemistry; Esters; Glutamine/chemistry; Guinea Pigs; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Substrate Specificity

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Collection: 01-internacional Database: MEDLINE Main subject: Transglutaminases / Liver Limits: Animals Language: En Journal: Biochemistry Year: 2001 Document type: Article Country of publication: United States

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