Interleukin-6 deficiency influences cytokine expression in susceptible BALB mice infected with Leishmania major but does not alter the outcome of disease.
Infect Immun
; 69(8): 5189-92, 2001 Aug.
Article
in En
| MEDLINE
| ID: mdl-11447205
ABSTRACT
Since interleukin-6 (IL-6) may promote Th2 responses, we infected BALB IL-6-deficient (IL-6(-/-)) mice with Leishmania major. There was not a significant difference between the courses of infection (lesion size and parasite burden) in IL-6(-/-) and wild-type mice, but IL-6(-/-) mice expressed lower levels of Th2- and Th1-associated cytokines.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Gene Expression Regulation
/
Cytokines
/
Interleukin-6
/
Leishmaniasis, Cutaneous
/
Leishmania major
Limits:
Animals
Language:
En
Journal:
Infect Immun
Year:
2001
Document type:
Article
Affiliation country:
United States