Lack of gender differences and large intrasubject variability in cytochrome P450 activity measured by phenotyping with dextromethorphan.

McCune, J S; Lindley, C; Decker, J L; Williamson, K M; Meadowcroft, A M; Graff, D; Sawyer, W T; Blough, D K; Pieper, J A

McCune, J S; Lindley, C; Decker, J L; Williamson, K M; Meadowcroft, A M; Graff, D; Sawyer, W T; Blough, D K; Pieper, J A.

Affiliation

McCune JS; University of Washington, Seattle, USA.

J Clin Pharmacol ; 41(7): 723-31, 2001 Jul.

Article in En | MEDLINE | ID: mdl-11452704

Subject(s)

Contraceptives, Oral, Combined/pharmacology; Cytochrome P-450 CYP2D6/metabolism; Cytochrome P-450 Enzyme System/metabolism; Dextromethorphan/metabolism; Ethinyl Estradiol-Norgestrel Combination/pharmacology; Excitatory Amino Acid Antagonists/metabolism; Menstruation/metabolism; Mixed Function Oxygenases/metabolism; Adult; Analysis of Variance; Cytochrome P-450 CYP2D6/genetics; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System/genetics; Dextromethorphan/urine; Excitatory Amino Acid Antagonists/urine; Female; Humans; Male; Mixed Function Oxygenases/genetics; Phenotype; Pilot Projects; Sex Characteristics

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Collection: 01-internacional Database: MEDLINE Main subject: Excitatory Amino Acid Antagonists / Contraceptives, Oral, Combined / Ethinyl Estradiol-Norgestrel Combination / Cytochrome P-450 CYP2D6 / Cytochrome P-450 Enzyme System / Dextromethorphan / Mixed Function Oxygenases / Menstruation Aspects: Determinantes_sociais_saude Limits: Adult / Female / Humans / Male Language: En Journal: J Clin Pharmacol Year: 2001 Document type: Article Affiliation country: United States Country of publication: United kingdom

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