Roles and mechanisms of action of pituitary adenylate cyclase-activating polypeptide (PACAP) in growth hormone and prolactin secretion.

Murakami, Y; Koshimura, K; Yamauchi, K; Nishiki, M; Tanaka, J; Kato, Y

Murakami, Y; Koshimura, K; Yamauchi, K; Nishiki, M; Tanaka, J; Kato, Y.

Affiliation

Murakami Y; Department of Medicine, Shimane Medical University, Izumo, Japan.

Endocr J ; 48(2): 123-32, 2001 Apr.

Article in En | MEDLINE | ID: mdl-11456257

ABSTRACT

ABSTRACT

It appears that PACAP has a direct action on somatotrophs to release GH. The intracellular signal transduction mechanisms for PACAP might be similar to but partly distinct from those for GRH. PACAP might play a role in GH secretion induced by serotoninergic mechanisms but not in ultradian rhythm of GH secretion in the rat. PACAP can stimulate PRL release from the pituitary in rats possibly through indirect paracrine effect. In addition, PACAP might participate in regulation of PRL secretion via hypothalamic VIP.

Subject(s)

Growth Hormone/metabolism; Neuropeptides/physiology; Adenoma/metabolism; Animals; Cells, Cultured; Humans; Hypothalamus/chemistry; Hypothalamus/drug effects; Hypothalamus/physiology; Neuropeptides/analysis; Neuropeptides/pharmacology; Pituitary Adenylate Cyclase-Activating Polypeptide; Pituitary Gland/chemistry; Pituitary Gland/drug effects; Pituitary Gland/physiology; Pituitary Neoplasms/metabolism; Prolactin/metabolism; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide; Receptors, Pituitary Hormone/analysis; Receptors, Pituitary Hormone/physiology

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Collection: 01-internacional Database: MEDLINE Main subject: Neuropeptides / Growth Hormone Limits: Animals / Humans Language: En Journal: Endocr J Journal subject: ENDOCRINOLOGIA Year: 2001 Document type: Article Affiliation country: Japan Publication country: JAPAN / JAPON / JAPÃO / JP

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