Effect of lithium on phosphoinositide metabolism in human brain: a proton decoupled (31)P magnetic resonance spectroscopy study.
Biol Psychiatry
; 50(1): 3-7, 2001 Jul 01.
Article
in En
| MEDLINE
| ID: mdl-11457417
ABSTRACT
BACKGROUND:
The objective of our study was to evaluate whether lithium increases brain phosphomonoester (PME) levels in human subjects.METHODS:
Proton decoupled (31)P magnetic resonance spectra were obtained from eight healthy volunteers before and after the administration of lithium carbonate, 450 mg b.i.d., for 7 and 14 days.RESULTS:
Pairwise comparisons of the mole percent PME revealed a significant increase from baseline at day 7 and day 14 of lithium administration.CONCLUSIONS:
An increase in PME concentration with 7 and 14 days of lithium administration in the human brain in vivo was observed. Because the inositol-1-monophosphate contributes to the PME peak, this result suggests that some of the initial actions of lithium may occur through a reduction of myo-inositol, which in turn may initiate a cascade of secondary changes at different levels of signal transduction process and gene expression in brain, effects that are ultimately responsible for the therapeutic benefits of lithium.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phosphatidylinositols
/
Protons
/
Brain
/
Magnetic Resonance Spectroscopy
/
Lithium Carbonate
/
Antimanic Agents
Type of study:
Observational_studies
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Biol Psychiatry
Year:
2001
Document type:
Article
Affiliation country:
Turkey