A novel autocrine pathway of tumor escape from immune recognition: melanoma cell lines produce a soluble protein that diminishes expression of the gene encoding the melanocyte lineage melan-A/MART-1 antigen through down-modulation of its promoter.

Kurnick, J T; Ramirez-Montagut, T; Boyle, L A; Andrews, D M; Pandolfi, F; Durda, P J; Butera, D; Dunn, I S; Benson, E M; Gobin, S J; van den Elsen, P J

Kurnick, J T; Ramirez-Montagut, T; Boyle, L A; Andrews, D M; Pandolfi, F; Durda, P J; Butera, D; Dunn, I S; Benson, E M; Gobin, S J; van den Elsen, P J.

Affiliation

Kurnick JT; Department of Pathology, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114, USA. kurnick@helix.mgh.harvard.edu

J Immunol ; 167(3): 1204-11, 2001 Aug 01.

Article in En | MEDLINE | ID: mdl-11466335

Subject(s)

Autocrine Communication/immunology; Down-Regulation/immunology; Melanoma/immunology; Neoplasm Proteins/antagonists & inhibitors; Neoplasm Proteins/biosynthesis; Neoplasm Proteins/genetics; Promoter Regions, Genetic/immunology; Tumor Escape/immunology; Antigens, Neoplasm; Coculture Techniques; Cytotoxicity Tests, Immunologic; Down-Regulation/genetics; Gene Silencing/immunology; Humans; Jurkat Cells; MART-1 Antigen; Melanocytes/immunology; Neoplasm Proteins/physiology; RNA, Messenger/antagonists & inhibitors; RNA, Messenger/metabolism; Solubility; T-Lymphocytes, Cytotoxic/immunology; T-Lymphocytes, Cytotoxic/metabolism; Transcription, Genetic/immunology; Tumor Cells, Cultured

Search on Google

Add to My VHL

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Down-Regulation / Promoter Regions, Genetic / Tumor Escape / Autocrine Communication / Melanoma / Neoplasm Proteins Limits: Humans Language: En Journal: J Immunol Year: 2001 Document type: Article Affiliation country: United States Country of publication: United States

Search on Google

Add to My VHL

XML

PubMed Links