MHC class I-restricted determinants on the glutamic acid decarboxylase 65 molecule induce spontaneous CTL activity.

Quinn, A; McInerney, M F; Sercarz, E E

Quinn, A; McInerney, M F; Sercarz, E E.

Affiliation

Quinn A; Division of Immune Regulation, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA.

J Immunol ; 167(3): 1748-57, 2001 Aug 01.

Article in En | MEDLINE | ID: mdl-11466400

Subject(s)

Cytotoxicity, Immunologic/immunology; Epitopes, T-Lymphocyte/immunology; Glutamate Decarboxylase/immunology; H-2 Antigens/immunology; Immunodominant Epitopes/immunology; Isoenzymes/immunology; T-Lymphocytes, Cytotoxic/enzymology; T-Lymphocytes, Cytotoxic/immunology; Administration, Intranasal; Aging/immunology; Animals; Animals, Newborn; Animals, Suckling; CD8-Positive T-Lymphocytes/enzymology; CD8-Positive T-Lymphocytes/immunology; Cell Line; Cyclophosphamide/administration & dosage; Cytotoxicity Tests, Immunologic; Diabetes Mellitus, Type 1/immunology; Diabetes Mellitus, Type 1/prevention & control; Female; Freund's Adjuvant/administration & dosage; Glutamate Decarboxylase/administration & dosage; Glutamate Decarboxylase/genetics; Injections, Intraperitoneal; Isoenzymes/administration & dosage; Isoenzymes/genetics; Mice; Mice, Inbred BALB C; Mice, Inbred NOD; Mice, SCID; Peptide Fragments/administration & dosage; Peptide Fragments/immunology; Rats; Spleen/cytology; Spleen/immunology; T-Lymphocyte Subsets/enzymology; T-Lymphocyte Subsets/immunology; Transfection

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Collection: 01-internacional Database: MEDLINE Main subject: T-Lymphocytes, Cytotoxic / H-2 Antigens / Immunodominant Epitopes / Epitopes, T-Lymphocyte / Cytotoxicity, Immunologic / Glutamate Decarboxylase / Isoenzymes Language: En Journal: J Immunol Year: 2001 Document type: Article Affiliation country: United States Country of publication: United States

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