Group I metabotropic glutamate receptors elicit epileptiform discharges in the hippocampus through PLCbeta1 signaling.

Chuang, S C; Bianchi, R; Kim, D; Shin, H S; Wong, R K

Chuang, S C; Bianchi, R; Kim, D; Shin, H S; Wong, R K.

Affiliation

Chuang SC; Department of Physiology and Pharmacology, State University of New York-Health Science Center at Brooklyn, Brooklyn, New York 11203, USA.

J Neurosci ; 21(16): 6387-94, 2001 Aug 15.

Article in En | MEDLINE | ID: mdl-11487662

Subject(s)

Epilepsy/physiopathology; Hippocampus/physiopathology; Isoenzymes/metabolism; Receptors, Metabotropic Glutamate/metabolism; Signal Transduction; Type C Phospholipases/metabolism; Animals; Biological Clocks; Cell Membrane/metabolism; Crosses, Genetic; Enzyme Inhibitors/pharmacology; Excitatory Amino Acid Agonists/pharmacology; Glycine/analogs & derivatives; Glycine/pharmacology; Hippocampus/drug effects; Homozygote; In Vitro Techniques; Isoenzymes/antagonists & inhibitors; Isoenzymes/genetics; Mice; Mice, Inbred Strains; Mice, Knockout; Nerve Net/drug effects; Nerve Net/physiopathology; Neurons/drug effects; Neurons/metabolism; Patch-Clamp Techniques; Periodicity; Phospholipase C beta; Potassium/metabolism; Receptors, Metabotropic Glutamate/agonists; Resorcinols/pharmacology; Sensory Thresholds; Type C Phospholipases/antagonists & inhibitors; Type C Phospholipases/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Type C Phospholipases / Signal Transduction / Receptors, Metabotropic Glutamate / Epilepsy / Hippocampus / Isoenzymes Limits: Animals Language: En Journal: J Neurosci Year: 2001 Document type: Article Affiliation country: United States Country of publication: United States

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