A short course of high-dose cyclophosphamide induces long-term survival of intestinal allografts in mice.
Transpl Int
; 14(4): 261-5, 2001 Aug.
Article
in En
| MEDLINE
| ID: mdl-11512060
ABSTRACT
Several transplant programs have recently added cyclophosphamide (CyP) to their immune suppression protocols in an attempt to reduce intestinal graft rejection rates. The present study was undertaken to confirm the benefits of this drug in a murine small bowel transplant model. A short course of monotherapy with CyP 20 mg/kg per dose resulted in a mean survival time (MST) of 17.5 +/- 3.6 days, compared with a MST of 7.5 +/- 0.7 days in the untreated controls (P < 0.01). Cyclosporin A (CsA) 30 mg/kg per day produced comparable survival rates when used as monotherapy (MST 14.2 +/- 1.3 days) or in combination with CyP 20 mg/kg per dose (MST 21.3 +/- 5.1 days). Treatment with high dose CyP (40 mg/kg per dose) completely prevented graft loss in 8 of 10 animals (MST 72.5 +/- 5.3 days, P < 0.01). However, adding CsA abrogated the induction of long-term survival achieved by CyP alone (MST 23 +/- 0.4 days). These data have important implications for the use of CyP in clinical transplantation.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cyclophosphamide
/
Graft Survival
/
Immunosuppressive Agents
/
Intestine, Small
Type of study:
Guideline
Limits:
Animals
Language:
En
Journal:
Transpl Int
Journal subject:
TRANSPLANTE
Year:
2001
Document type:
Article