Dose staggering as a strategy to reduce drug--drug interactions due to reversible enzyme inhibition between orally administered drugs with high first pass effect: a computer simulation study.

Fang, J; McKay, G; Hubbard, J W; Hawes, E M; Midha, K K

Fang, J; McKay, G; Hubbard, J W; Hawes, E M; Midha, K K.

Affiliation

Fang J; College of Pharmacy and Nutrition, 110 Science Place, University of Saskatchewan, Saskatoon, Saskatchewan, Canada. fang@sask.usask.ca

Biopharm Drug Dispos ; 21(7): 249-59, 2000 Oct.

Article in En | MEDLINE | ID: mdl-11512125

Subject(s)

Computer Simulation; Drug Administration Schedule; Drug Interactions; Administration, Oral; Drug Combinations; Enzyme Inhibitors/pharmacokinetics; Pharmacokinetics; Portal Vein/metabolism; Time Factors

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Collection: 01-internacional Database: MEDLINE Main subject: Computer Simulation / Drug Administration Schedule / Drug Interactions Type of study: Prognostic_studies Language: En Journal: Biopharm Drug Dispos Year: 2000 Document type: Article Affiliation country: Canada Country of publication: United kingdom

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