Inhibitors of bacterial enoyl acyl carrier protein reductase (FabI): 2,9-disubstituted 1,2,3,4-tetrahydropyrido[3,4-b]indoles as potential antibacterial agents.

Seefeld, M A; Miller, W H; Newlander, K A; Burgess, W J; Payne, D J; Rittenhouse, S F; Moore, T D; DeWolf, W E; Keller, P M; Qiu, X; Janson, C A; Vaidya, K; Fosberry, A P; Smyth, M G; Jaworski, D D; Slater-Radosti, C; Huffman, W F

Seefeld, M A; Miller, W H; Newlander, K A; Burgess, W J; Payne, D J; Rittenhouse, S F; Moore, T D; DeWolf, W E; Keller, P M; Qiu, X; Janson, C A; Vaidya, K; Fosberry, A P; Smyth, M G; Jaworski, D D; Slater-Radosti, C; Huffman, W F.

Affiliation

Seefeld MA; GlaxoSmithKline Pharmaceuticals, Antimicrobial and Host Defense Division, 1250 S. Collegeville Road, Collegeville, PA 19426, USA. mark_a_seefeld@sbphrd.com

Bioorg Med Chem Lett ; 11(17): 2241-4, 2001 Sep 03.

Article in En | MEDLINE | ID: mdl-11527706

Subject(s)

Anti-Bacterial Agents/pharmacology; Enzyme Inhibitors/chemistry; Enzyme Inhibitors/pharmacology; Oxidoreductases/antagonists & inhibitors; Anti-Bacterial Agents/chemistry; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); Escherichia coli/drug effects; Escherichia coli Proteins; Fatty Acid Synthase, Type II; Inhibitory Concentration 50; Microbial Sensitivity Tests; Staphylococcus aureus/drug effects; Structure-Activity Relationship; Triclosan/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Oxidoreductases / Enzyme Inhibitors / Anti-Bacterial Agents Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2001 Document type: Article Affiliation country: United States

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