Tumorhead, a Xenopus gene product that inhibits neural differentiation through regulation of proliferation.
Development
; 128(17): 3381-93, 2001 Sep.
Article
in En
| MEDLINE
| ID: mdl-11546754
ABSTRACT
Tumorhead (TH) is a novel maternal gene product from Xenopus laevis containing several basic domains and a weak coiled-coil. Overexpression of wild-type TH resulted in increased proliferation of neural plate cells, causing expansion of the neural field followed by neural tube and craniofacial abnormalities. Overexpressed TH protein repressed neural differentiation and neural crest markers, but did not inhibit the neural inducers, pan-neural markers or mesodermal markers. Loss of function by injection of anti-TH antibody inhibited cell proliferation. Our data are consistent with a model in which tumorhead functions in regulating differentiation of the neural tissues but not neural induction or determination through its effect on cell proliferation.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Xenopus laevis
/
Proteins
/
Intercellular Signaling Peptides and Proteins
/
Neurons
Type of study:
Prognostic_studies
Language:
En
Journal:
Development
Journal subject:
BIOLOGIA
/
EMBRIOLOGIA
Year:
2001
Document type:
Article
Affiliation country:
United States