Modulation of penicillin acylase properties via immobilization techniques: one-pot chemoenzymatic synthesis of Cephamandole from Cephalosporin C.

Terreni, M; Pagani, G; Ubiali, D; Fernández-Lafuente, R; Mateo, C; Guisán, J M

Terreni, M; Pagani, G; Ubiali, D; Fernández-Lafuente, R; Mateo, C; Guisán, J M.

Affiliation

Terreni M; Pharmaceutical Biocatalysis Laboratories, Dipartimento di Chimica Farmaceutica, Università degli Studi di Pavia, via Taramelli 12, 27100, Pavia, Italy. markt@pbl.unipv.it

Bioorg Med Chem Lett ; 11(18): 2429-32, 2001 Sep 17.

Article in En | MEDLINE | ID: mdl-11549439

Subject(s)

Biochemistry/methods; Cefamandole/chemical synthesis; Cephalosporins/chemistry; Enzymes, Immobilized/chemistry; Penicillin Amidase/chemistry; Penicillin Amidase/metabolism; Cefamandole/metabolism; Cephalosporins/metabolism; Enzymes, Immobilized/metabolism; Escherichia coli/enzymology; Sepharose/chemistry

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Collection: 01-internacional Database: MEDLINE Main subject: Penicillin Amidase / Biochemistry / Cefamandole / Cephalosporins / Enzymes, Immobilized Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2001 Document type: Article Affiliation country: Italy Country of publication: United kingdom

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