Protection of hematopoietic cells from O(6)-alkylation damage by O(6)-methylguanine DNA methyltransferase gene transfer: studies with different O(6)-alkylating agents and retroviral backbones.

Jansen, M; Bardenheuer, W; Sorg, U R; Seeber, S; Flasshove, M; Moritz, T

Jansen, M; Bardenheuer, W; Sorg, U R; Seeber, S; Flasshove, M; Moritz, T.

Affiliation

Jansen M; Department of Internal Medicine (Cancer Research), West German Cancer Center, University of Essen Medical School, Essen, Germany.

Eur J Haematol ; 67(1): 2-13, 2001 Jul.

Article in En | MEDLINE | ID: mdl-11553261

Subject(s)

Alkylating Agents/toxicity; DNA Damage; Drug Resistance/genetics; Genetic Vectors/genetics; Hematopoietic Stem Cells/drug effects; O(6)-Methylguanine-DNA Methyltransferase/physiology; Retroviridae/genetics; Alkylation; Animals; Carmustine/toxicity; Cells, Cultured; Colony-Forming Units Assay; DNA, Complementary/genetics; Dacarbazine/analogs & derivatives; Dacarbazine/toxicity; Hematopoietic Stem Cells/enzymology; Humans; Lomustine/toxicity; Mice; Moloney murine leukemia virus/genetics; Nimustine/toxicity; O(6)-Methylguanine-DNA Methyltransferase/genetics; Recombinant Fusion Proteins/physiology; Sarcoma Viruses, Murine/genetics; Spleen Focus-Forming Viruses/genetics; Temozolomide; Terminal Repeat Sequences; Transfection

Search on Google

Add to My VHL

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Retroviridae / DNA Damage / Drug Resistance / Hematopoietic Stem Cells / O(6)-Methylguanine-DNA Methyltransferase / Alkylating Agents / Genetic Vectors Limits: Animals / Humans Language: En Journal: Eur J Haematol Journal subject: HEMATOLOGIA Year: 2001 Document type: Article Affiliation country: Germany Country of publication: United kingdom

Search on Google

Add to My VHL

XML

PubMed Links