New erythromycin derivatives from Saccharopolyspora erythraea using sugar O-methyltransferases from the spinosyn biosynthetic gene cluster.

Gaisser, S; Lill, R; Wirtz, G; Grolle, F; Staunton, J; Leadlay, P F

Gaisser, S; Lill, R; Wirtz, G; Grolle, F; Staunton, J; Leadlay, P F.

Affiliation

Gaisser S; Cambridge Centre for Molecular Recognition and Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK.

Mol Microbiol ; 41(5): 1223-31, 2001 Sep.

Article in En | MEDLINE | ID: mdl-11555300

Subject(s)

Anti-Bacterial Agents/biosynthesis; Erythromycin/analogs & derivatives; Erythromycin/biosynthesis; Methyltransferases/metabolism; Rhamnose/metabolism; Saccharopolyspora/enzymology; Anti-Bacterial Agents/chemistry; Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Culture Media; Erythromycin/chemistry; Gene Deletion; Genes, Bacterial; Mass Spectrometry/methods; Methyltransferases/genetics; Multigene Family; Plasmids/genetics; Saccharopolyspora/genetics; Saccharopolyspora/growth & development

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Collection: 01-internacional Database: MEDLINE Main subject: Rhamnose / Erythromycin / Saccharopolyspora / Methyltransferases / Anti-Bacterial Agents Language: En Journal: Mol Microbiol Journal subject: BIOLOGIA MOLECULAR / MICROBIOLOGIA Year: 2001 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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