Synthesis and hypoglycemic activity of some new flavone derivatives. 4th communication: 6-flavonyl-2,4-thiazolidinediones.

ABSTRACT

A new series of flavonyl compounds (1-10) was prepared and tested for their insulinotropic activities in INS-1 cells. Compounds 2, 5 and 6 (at higher concentrations) and compounds 3 and 7-10 were able to increase insulin release in the presence of 5.6 mmol/l glucose at both concentrations used (1 and 10 micrograms/ml).