Diagnostic utility of microphthalmia transcription factor in malignant melanoma and other tumors.
Adv Anat Pathol
; 8(5): 273-5, 2001 Sep.
Article
in En
| MEDLINE
| ID: mdl-11556535
ABSTRACT
The diagnosis of malignant melanoma is sometimes challenging. Immunohistochemistry for specific markers of melanocytic differentiation such as HMB-45 and Melan-A can be very valuable in proving melanocytic differentiation in poorly differentiated or spindled forms of melanoma. Microphthalmia-associated transcription factor (MiTF) is the most recently described and the only nuclear melanocytic marker. This article reviews the biology of MiTF and those published studies that have addressed its diagnostic sensitivity and specificity. MiTF may be very valuable for the diagnosis of melanoma, including desmoplastic variants; melanocytic soft tissue tumors, such as clear cell sarcoma; and the unusual group of tumors that show combined melanocytic and myoid differentiation, the perivascular epithelioid cell family of tumors (PEComas).
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Skin Neoplasms
/
Transcription Factors
/
DNA-Binding Proteins
/
Melanoma
/
Antibodies, Monoclonal
Type of study:
Diagnostic_studies
Limits:
Humans
Language:
En
Journal:
Adv Anat Pathol
Journal subject:
ANATOMIA
/
PATOLOGIA
Year:
2001
Document type:
Article
Affiliation country:
United States