Molecular mechanisms of nociception.
Nature
; 413(6852): 203-10, 2001 Sep 13.
Article
in En
| MEDLINE
| ID: mdl-11557989
ABSTRACT
The sensation of pain alerts us to real or impending injury and triggers appropriate protective responses. Unfortunately, pain often outlives its usefulness as a warning system and instead becomes chronic and debilitating. This transition to a chronic phase involves changes within the spinal cord and brain, but there is also remarkable modulation where pain messages are initiated - at the level of the primary sensory neuron. Efforts to determine how these neurons detect pain-producing stimuli of a thermal, mechanical or chemical nature have revealed new signalling mechanisms and brought us closer to understanding the molecular events that facilitate transitions from acute to persistent pain.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pain
/
Neurons, Afferent
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Nature
Year:
2001
Document type:
Article
Affiliation country:
United States