Lung tumor KRAS and TP53 mutations in nonsmokers reflect exposure to PAH-rich coal combustion emissions.
Cancer Res
; 61(18): 6679-81, 2001 Sep 15.
Article
in En
| MEDLINE
| ID: mdl-11559534
ABSTRACT
We determined the TP53 and codon 12 KRAS mutations in lung tumors from 24 nonsmokers whose tumors were associated with exposure to smoky coal. Among any tumors studied previously, these showed the highest percentage of mutations that (a) were G --> T transversions at either KRAS (86%) or TP53 (76%), (b) clustered at the G-rich codons 153-158 of TP53 (33%), and (c) had 100% of the guanines of the G --> T transversions on the nontranscribed strand. This mutation spectrum is consistent with an exposure to polycyclic aromatic hydrocarbons, which are the primary component of the smoky coal emissions. These results show that mutations in the TP53 and KRAS genes can reflect a specific environmental exposure.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Polycyclic Aromatic Hydrocarbons
/
Genes, p53
/
Genes, ras
/
Coal
/
Lung Neoplasms
/
Mutation
Type of study:
Etiology_studies
Limits:
Female
/
Humans
/
Middle aged
Language:
En
Journal:
Cancer Res
Year:
2001
Document type:
Article
Affiliation country:
United States