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Genome-wide scan for Parkinson's disease: the GenePD Study.
DeStefano, A L; Golbe, L I; Mark, M H; Lazzarini, A M; Maher, N E; Saint-Hilaire, M; Feldman, R G; Guttman, M; Watts, R L; Suchowersky, O; Lafontaine, A L; Labelle, N; Lew, M F; Waters, C H; Growdon, J H; Singer, C; Currie, L J; Wooten, G F; Vieregge, P; Pramstaller, P P; Klein, C; Hubble, J P; Stacy, M; Montgomery, E; MacDonald, M E; Gusella, J F; Myers, R H.
Affiliation
  • DeStefano AL; Department of Neurology, Boston University Schools of Medicine and of Public Health, Boston, MA 02118, USA.
Neurology ; 57(6): 1124-6, 2001 Sep 25.
Article in En | MEDLINE | ID: mdl-11571351
A genome-wide scan for idiopathic PD in a sample of 113 PD-affected sibling pairs is reported. Suggestive evidence for linkage was found for chromosomes 1 (214 cM, lod = 1.20), 9 (136 cM, lod = 1.30), 10 (88 cM, lod = 1.07), and 16 (114 cM, lod = 0.93). The chromosome 9 region overlaps the genes for dopamine beta-hydroxylase and torsion dystonia. Although no strong evidence for linkage was found for any locus, these results may be of value in comparison with similar studies by others.
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Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease / Genetic Testing / Genome Type of study: Diagnostic_studies / Prognostic_studies Limits: Aged / Humans / Male / Middle aged Language: En Journal: Neurology Year: 2001 Document type: Article Affiliation country: United States Country of publication: United States
Search on Google
Add to My VHL
Print
XML
PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease / Genetic Testing / Genome Type of study: Diagnostic_studies / Prognostic_studies Limits: Aged / Humans / Male / Middle aged Language: En Journal: Neurology Year: 2001 Document type: Article Affiliation country: United States Country of publication: United States