Crystal structure of human macrophage elastase (MMP-12) in complex with a hydroxamic acid inhibitor.

Nar, H; Werle, K; Bauer, M M; Dollinger, H; Jung, B

Nar, H; Werle, K; Bauer, M M; Dollinger, H; Jung, B.

Affiliation

Nar H; Department of Medicinal Chemistry, Boehringer Ingelheim Pharma KG, Biberach, Germany. herbert.nar@bc.boehringer-ingelheim.com

J Mol Biol ; 312(4): 743-51, 2001 Sep 28.

Article in En | MEDLINE | ID: mdl-11575929

Subject(s)

Hydroxamic Acids/metabolism; Metalloendopeptidases/antagonists & inhibitors; Metalloendopeptidases/chemistry; Protease Inhibitors/metabolism; Pyrazines; Amino Acid Sequence; Binding Sites; Cations, Divalent/metabolism; Crystallization; Crystallography, X-Ray; Drug Design; Humans; Hydrogen Bonding; Hydroxamic Acids/chemistry; Macrophages/enzymology; Matrix Metalloproteinase 12; Metalloendopeptidases/metabolism; Models, Molecular; Molecular Sequence Data; Protease Inhibitors/chemistry; Protein Conformation; Sequence Alignment; Substrate Specificity; Sulfonamides; Zinc/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Protease Inhibitors / Pyrazines / Metalloendopeptidases / Hydroxamic Acids Limits: Humans Language: En Journal: J Mol Biol Year: 2001 Document type: Article Affiliation country: Germany Country of publication: Netherlands

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