Manganese mimics the action of 1-methyl-4-phenylpyridinium ion, a dopaminergic neurotoxin, in rat striatal tissue slices.

Hirata, Y; Kiuchi, K; Nagatsu, T

Hirata, Y; Kiuchi, K; Nagatsu, T.

Affiliation

Hirata Y; Laboratory for Genes of Motor Systems, Bio-Mimetic Control Research Center, RIKEN, 2271-130, Anagahora, Shimoshidami, Moriyama, 463-0003, Nagoya, Japan.yoko@bmc.riken.go.jp

Neurosci Lett ; 311(1): 53-6, 2001 Sep 21.

Article in En | MEDLINE | ID: mdl-11585566

Subject(s)

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/pharmacology; Dopamine/metabolism; MPTP Poisoning/metabolism; Manganese Poisoning/metabolism; Manganese/pharmacology; Neostriatum/drug effects; Neurotoxins/pharmacology; Animals; Dihydroxyphenylalanine/biosynthesis; Dihydroxyphenylalanine/drug effects; Dose-Response Relationship, Drug; Glycolysis/drug effects; Glycolysis/physiology; Hydroxylation/drug effects; Lactic Acid/metabolism; MPTP Poisoning/physiopathology; Male; Manganese Poisoning/pathology; Manganese Poisoning/physiopathology; Neostriatum/metabolism; Neostriatum/physiopathology; Rats; Rats, Wistar; Tyrosine/drug effects; Tyrosine/metabolism; Tyrosine 3-Monooxygenase/antagonists & inhibitors; Tyrosine 3-Monooxygenase/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Dopamine / 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Neostriatum / MPTP Poisoning / Manganese Poisoning / Manganese / Neurotoxins Limits: Animals Language: En Journal: Neurosci Lett Year: 2001 Document type: Article Country of publication: Ireland

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