Demethylation by 5-aza-2'-deoxycytidine (5-azadC) of p16INK4A gene results in downregulation of vascular endothelial growth factor expression in human lung cancer cell lines.

Miki, K; Shimizu, E; Yano, S; Tani, K; Sone, S

Miki, K; Shimizu, E; Yano, S; Tani, K; Sone, S.

Affiliation

Miki K; Third Department of Internal Medicine, University of Tokushima School of Medicine, Japan.

Oncol Res ; 12(8): 335-42, 2001.

Article in En | MEDLINE | ID: mdl-11589304

Subject(s)

Antimetabolites, Antineoplastic/pharmacology; Azacitidine/analogs & derivatives; Azacitidine/pharmacology; Endothelial Growth Factors/metabolism; Genes, p16; Lung Neoplasms/genetics; Lung Neoplasms/metabolism; Lymphokines/metabolism; Cell Division/drug effects; DNA Methylation; DNA Modification Methylases/antagonists & inhibitors; Decitabine; Dose-Response Relationship, Drug; Down-Regulation; Endothelial Growth Factors/genetics; Enzyme Inhibitors/pharmacology; Gene Expression Regulation, Neoplastic; Genes, Dominant; Humans; Interleukin-8/genetics; Kinetics; Lymphokines/genetics; Promoter Regions, Genetic; Protein Isoforms/genetics; Protein Isoforms/metabolism; RNA, Neoplasm/biosynthesis; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

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Collection: 01-internacional Database: MEDLINE Main subject: Azacitidine / Endothelial Growth Factors / Lymphokines / Genes, p16 / Lung Neoplasms / Antimetabolites, Antineoplastic Limits: Humans Language: En Journal: Oncol Res Journal subject: NEOPLASIAS Year: 2001 Document type: Article Affiliation country: Japan Country of publication: United States

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