Predicting octanol/water partition coefficient using solvation free energy and solvent-accessible surface area.
J Environ Sci (China)
; 13(3): 299-303, 2001 Jul.
Article
in En
| MEDLINE
| ID: mdl-11590759
ABSTRACT
The regression model for octanol/water partition coefficients (Kow), is founded with only two molecular descriptors available through quantum chemical calculations solvation free energy (delta Gs), and solvent-accessible surface area (SASA). For the properties of 47 organic compounds from 17 types, the model gives a correction coefficient (adjusted for degrees of freedom) of 0.959 and a standard error of 0.277 log unit. It is a suitable way to predict the partition properties that are related to solute-solvent interactions in the water phase.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Solvents
/
Water
/
Octanols
Type of study:
Diagnostic_studies
/
Prognostic_studies
/
Risk_factors_studies
Language:
En
Journal:
J Environ Sci (China)
Journal subject:
SAUDE AMBIENTAL
Year:
2001
Document type:
Article
Affiliation country:
China