Mildly oxidized LDL induces activation of platelet-derived growth factor beta-receptor pathway.

Escargueil-Blanc, I; Salvayre, R; Vacaresse, N; Jürgens, G; Darblade, B; Arnal, J F; Parthasarathy, S; Nègre-Salvayre, A

Escargueil-Blanc, I; Salvayre, R; Vacaresse, N; Jürgens, G; Darblade, B; Arnal, J F; Parthasarathy, S; Nègre-Salvayre, A.

Affiliation

Escargueil-Blanc I; INSERM U-466 and the Biochemistry Department, IFR-31, CHU Rangueil, Toulouse, France.

Circulation ; 104(15): 1814-21, 2001 Oct 09.

Article in En | MEDLINE | ID: mdl-11591620

Subject(s)

Lipoproteins, LDL/metabolism; Macrolides; Muscle, Smooth, Vascular/metabolism; Receptor, Platelet-Derived Growth Factor beta/metabolism; Signal Transduction/physiology; Aldehydes/metabolism; Aldehydes/pharmacology; Animals; Anti-Bacterial Agents/pharmacology; Antioxidants/pharmacology; Aorta/metabolism; Aorta/pathology; Arteriosclerosis/chemically induced; Arteriosclerosis/metabolism; Arteriosclerosis/pathology; Autocrine Communication; Cells, Cultured; Ceramides/metabolism; Chloroquine/pharmacology; Diet, Atherogenic; Enzyme Inhibitors/pharmacology; Humans; Hydrogen Peroxide/metabolism; Lipoproteins, LDL/pharmacology; Male; Muscle, Smooth, Vascular/cytology; Muscle, Smooth, Vascular/drug effects; Oxidative Stress/physiology; Phosphorylation/drug effects; Rabbits; Reactive Oxygen Species/metabolism; Signal Transduction/drug effects; Sphingomyelins/metabolism; Tyrosine/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Macrolides / Receptor, Platelet-Derived Growth Factor beta / Lipoproteins, LDL / Muscle, Smooth, Vascular Limits: Animals / Humans / Male Language: En Journal: Circulation Year: 2001 Document type: Article Affiliation country: France Country of publication: United States

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