CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration.
Cell
; 107(1): 27-41, 2001 Oct 05.
Article
in En
| MEDLINE
| ID: mdl-11595183
ABSTRACT
The C. elegans genes ced-2, ced-5, and ced-10, and their mammalian homologs crkII, dock180, and rac1, mediate cytoskeletal rearrangements during phagocytosis of apoptotic cells and cell motility. Here, we describe an additional member of this signaling pathway, ced-12, and its mammalian homologs, elmo1 and elmo2. In C. elegans, CED-12 is required for engulfment of dying cells and for cell migrations. In mammalian cells, ELMO1 functionally cooperates with CrkII and Dock180 to promote phagocytosis and cell shape changes. CED-12/ELMO-1 binds directly to CED-5/Dock180; this evolutionarily conserved complex stimulates a Rac-GEF, leading to Rac1 activation and cytoskeletal rearrangements. These studies identify CED-12/ELMO as an upstream regulator of Rac1 that affects engulfment and cell migration from C. elegans to mammals.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phagocytosis
/
Carrier Proteins
/
Helminth Proteins
/
Cell Movement
/
Proto-Oncogene Proteins
/
Caenorhabditis elegans
/
Rac GTP-Binding Proteins
/
Cytoskeletal Proteins
/
Caenorhabditis elegans Proteins
/
Adaptor Proteins, Signal Transducing
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
/
Male
Language:
En
Journal:
Cell
Year:
2001
Document type:
Article
Affiliation country:
United States