Oxidation mechanism of 7-hydroxy-delta 8-tetrahydrocannabinol and 8-hydroxy-delta 9-tetrahydrocannabinol to the corresponding ketones by CYP3A11.

Matsunaga, T; Tanaka, H; Higuchi, S; Shibayama, K; Kishi, N; Watanabe, K; Yamamoto, I

Matsunaga, T; Tanaka, H; Higuchi, S; Shibayama, K; Kishi, N; Watanabe, K; Yamamoto, I.

Affiliation

Matsunaga T; Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa 920-1181, Japan.

Drug Metab Dispos ; 29(11): 1485-91, 2001 Nov.

Article in En | MEDLINE | ID: mdl-11602526

Subject(s)

Cytochrome P-450 Enzyme System/metabolism; Dronabinol/analogs & derivatives; Dronabinol/metabolism; Ketones/metabolism; Animals; COS Cells/enzymology; Cloning, Molecular; Cytochrome P-450 Enzyme System/biosynthesis; Cytochrome P-450 Enzyme System/genetics; Guinea Pigs; Male; Mice; Mice, Inbred C57BL; Microsomes, Liver/enzymology; Oxidation-Reduction

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Collection: 01-internacional Database: MEDLINE Main subject: Dronabinol / Cytochrome P-450 Enzyme System / Ketones Limits: Animals Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 2001 Document type: Article Affiliation country: Japan Country of publication: United States

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