Integrated effects of the vasodilating beta-blocker nebivolol on exercise performance, energy metabolism, cardiovascular and neurohormonal parameters in physically active patients with arterial hypertension.
J Hum Hypertens
; 15(10): 715-21, 2001 Oct.
Article
in En
| MEDLINE
| ID: mdl-11607802
ABSTRACT
OBJECTIVE:
The present study was designed to investigate the integrated effects of the beta-1-selective blocker with vasodilator properties, nebivolol, on systemic haemodynamics, neurohormones and energy metabolism as well as oxygen uptake and exercise performance in physically active patients with moderate essential hypertension (EH). DESIGN ANDMETHODS:
Eighteen physically active patients with moderate EH were included age 46.9 +/- 2.38 years, weight 83.9 +/- 2.81 kg, blood pressure (BP) 155.8 +/- 3.90/102.5 +/- 1.86 mm Hg, heart rate 73.6 +/- 2.98 min(-1). After a 14-day wash-out period a bicycle spiroergometry until exhaustion (WHO) was performed followed by a 45-min submaximal exercise test on the 2.5 mmol/l lactate-level 48 h later. Before, during and directly after exercise testing blood samples were taken. An identical protocol was repeated after a 6-week treatment period with 5 mg nebivolol/day.RESULTS:
Nebivolol treatment resulted in a significant (P < 0.01) decrease in systolic and diastolic BP and heart rate at rest and during maximal and submaximal exercise. Maximal physical work performance, blood lactate and rel. oxygen uptake (rel. VO(2)) before and after nebivolol treatment at rest and during maximal and submaximal exercise remained unaltered. Free fatty acid, free glycerol, plasma catecholamines, beta-endorphines and atrial natriuretic peptide (ANP) increased before and after treatment during maximal and submaximal exercise but remained unaltered by nebivolol treatment. In contrast, plasma ANP levels at rest were significantly higher in the presence of nebivolol, endothelin-1 levels were unchanged.CONCLUSIONS:
Nebivolol was effective in the control of BP at rest and during exercise in patients with EH. Furthermore, nebivolol did not negatively affect lipid and carbohydrate metabolism and substrate flow. The explanation for the effects on ANP at rest remain elusive. This pharmacodynamic profile of nebivolol is potentially suitable in physically active patients with EH.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Vasodilator Agents
/
Benzopyrans
/
Physical Fitness
/
Adrenergic beta-Antagonists
/
Energy Metabolism
/
Ethanolamines
/
Physical Exertion
/
Hemodynamics
/
Hypertension
/
Neurosecretory Systems
Type of study:
Guideline
Limits:
Adult
/
Humans
/
Middle aged
Language:
En
Journal:
J Hum Hypertens
Journal subject:
ANGIOLOGIA
Year:
2001
Document type:
Article
Affiliation country:
Germany