Angiotensin-converting enzyme gene polymorphism and microvascular complications in Turkish type 2 diabetic patients.
Diabetes Res Clin Pract
; 54(2): 95-104, 2001 Nov.
Article
in En
| MEDLINE
| ID: mdl-11640993
ABSTRACT
The aim of this study was to investigate whether an association exists between the angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism and microvascular complications of type 2 diabetes mellitus in Turkish patients. A total of 239 type 2 diabetic patients and 138 sex and age matched control subjects were included into the study. The I/D polymorphism was determined by polymerase chain reaction (PCR). Nephropathy status was determined according to urinary albumin/creatinine ratio (microg/mg) (<30 normoalbuminuria, 30-300 microalbuminuria, >300 macroalbuminuria) and retinopathy was evaluated by fundoscopic examination and by flourescein fundus angiography. The distribution of ACE I/D polymorphism and allele frequencies in diabetic patients were not significantly different from controls, DD genotype 32.2 versus 37.2%; ID genotype 50.6 versus 47.1%; and II 17.2 versus 15.2%; D allele 57.5 versus 61.2%; I allele 42.5 versus 38.8%. Genotype distribution between normo-, micro- and macroalbuminuric patients did not differ significantly (DDIDII (%), normoalbuminuria, 354619; microalbuminuria, 285517; macroalbuminuria, 315514). There was also no difference in genotype distribution between patients with and without retinopathy (DDIDII (%), retinopathy positive, 325117; retinopathy negative, 334918). In conclusion, the ACE I/D polymorphism does not seem to be associated with diabetic nephropathy and retinopathy in Turkish type 2 diabetic patients.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Polymorphism, Genetic
/
Peptidyl-Dipeptidase A
/
Diabetes Mellitus, Type 2
/
Diabetic Angiopathies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Asia
Language:
En
Journal:
Diabetes Res Clin Pract
Journal subject:
ENDOCRINOLOGIA
Year:
2001
Document type:
Article
Affiliation country:
Turkey