Clearance of human herpesvirus 8 from blood and regression of leukopenia-associated aggressive classic Kaposi's sarcoma during interferon-alpha therapy: a case report.
Clin Infect Dis
; 33(10): 1782-5, 2001 Nov 15.
Article
in En
| MEDLINE
| ID: mdl-11641829
ABSTRACT
A human immunodeficiency virus-negative woman with severe classic Kaposi's sarcoma, idiopathic leukopenia, and massive spread of human herpesvirus 8 (HHV-8) in circulating cells showed stable disease remission in response to systemic interferon-alpha treatment that was accompanied by increased CD3(+) and CD4(+) T cell numbers and complete clearance of HHV-8 from the circulation. These results suggest a direct relationship between HHV-8 clearance from blood and regression of Kaposi's sarcoma and are consistent with the in vitro inhibitory effects of interferon-alpha on HHV-8 infection.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Sarcoma, Kaposi
/
DNA, Viral
/
Interferon-alpha
/
Herpesvirus 8, Human
/
Leukopenia
Type of study:
Risk_factors_studies
Limits:
Female
/
Humans
Language:
En
Journal:
Clin Infect Dis
Journal subject:
DOENCAS TRANSMISSIVEIS
Year:
2001
Document type:
Article
Affiliation country:
Italy