Beta(2)-microglobulin and its deamidated variant, N17D form amyloid fibrils with a range of morphologies in vitro.

Kad, N M; Thomson, N H; Smith, D P; Smith, D A; Radford, S E

Kad, N M; Thomson, N H; Smith, D P; Smith, D A; Radford, S E.

Affiliation

Kad NM; School of Biochemistry and Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK.

J Mol Biol ; 313(3): 559-71, 2001 Oct 26.

Article in En | MEDLINE | ID: mdl-11676539

Subject(s)

Amino Acid Substitution/genetics; Amyloidosis/metabolism; beta 2-Microglobulin/chemistry; beta 2-Microglobulin/metabolism; Amyloidosis/genetics; Circular Dichroism; Congo Red; Fluorescence; Genetic Variation/genetics; Humans; Hydrogen-Ion Concentration; Kinetics; Microscopy, Atomic Force; Microscopy, Electron; Models, Molecular; Osmolar Concentration; Protein Binding; Protein Denaturation/drug effects; Protein Folding; Protein Structure, Quaternary; Recombinant Proteins/chemistry; Recombinant Proteins/metabolism; Recombinant Proteins/ultrastructure; Renal Dialysis; Thermodynamics; Ultracentrifugation; Urea/pharmacology; beta 2-Microglobulin/genetics; beta 2-Microglobulin/ultrastructure

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Collection: 01-internacional Database: MEDLINE Main subject: Beta 2-Microglobulin / Amino Acid Substitution / Amyloidosis Limits: Humans Language: En Journal: J Mol Biol Year: 2001 Document type: Article Affiliation country: United kingdom Country of publication: Netherlands

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