In vitro and in vivo transfer of bcl-2 gene into keratinocytes suppresses UVB-induced apoptosis.

Takahashi, H; Honma, M; Ishida-Yamamoto, A; Namikawa, K; Miwa, A; Okado, H; Kiyama, H; Iizuka, H

Takahashi, H; Honma, M; Ishida-Yamamoto, A; Namikawa, K; Miwa, A; Okado, H; Kiyama, H; Iizuka, H.

Affiliation

Takahashi H; Department of Dermatology, Asahikawa Medical College, 2-1-1 Midorigaoka higashi, Asahikawa 078-8510, Japan. ht@asahikawa-med.ac.jp

Photochem Photobiol ; 74(4): 579-86, 2001 Oct.

Article in En | MEDLINE | ID: mdl-11683038

Subject(s)

Apoptosis/radiation effects; Caspase 1/metabolism; Caspases/metabolism; Cells, Cultured/radiation effects; Enzyme Inhibitors/metabolism; Gene Expression Regulation/radiation effects; Keratinocytes; Proto-Oncogene Proteins c-bcl-2; Skin; Ultraviolet Rays/adverse effects; Adenoviridae; Animals; Blotting, Western; Caspase 3; Caspase 8; Caspase 9; Caspase Inhibitors; Cell Survival/radiation effects; Cells, Cultured/metabolism; Dose-Response Relationship, Radiation; Enzyme Activation/radiation effects; Enzyme Inhibitors/radiation effects; Epidermis/metabolism; Epidermis/radiation effects; Genes, bcl-2; Genetic Vectors; Histocytochemistry; Humans; In Vitro Techniques; Keratinocytes/enzymology; Keratinocytes/metabolism; Keratinocytes/radiation effects; Mice; Mice, Inbred BALB C; Proto-Oncogene Proteins c-bcl-2/genetics; Proto-Oncogene Proteins c-bcl-2/metabolism; Skin/cytology; Skin/enzymology; Skin/metabolism; Skin/radiation effects; Transfection

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Collection: 01-internacional Database: MEDLINE Main subject: Skin / Ultraviolet Rays / Keratinocytes / Cells, Cultured / Gene Expression Regulation / Apoptosis / Proto-Oncogene Proteins c-bcl-2 / Caspases / Caspase 1 / Enzyme Inhibitors Language: En Journal: Photochem Photobiol Year: 2001 Document type: Article Affiliation country: Japan

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