Characterization of indolinones which preferentially inhibit VEGF-C- and VEGF-D-induced activation of VEGFR-3 rather than VEGFR-2.

Kirkin, V; Mazitschek, R; Krishnan, J; Steffen, A; Waltenberger, J; Pepper, M S; Giannis, A; Sleeman, J P

Kirkin, V; Mazitschek, R; Krishnan, J; Steffen, A; Waltenberger, J; Pepper, M S; Giannis, A; Sleeman, J P.

Affiliation

Kirkin V; Forschungszentrum Karlsruhe, Institute of Genetics, Karlsruhe, Germany.

Eur J Biochem ; 268(21): 5530-40, 2001 Nov.

Article in En | MEDLINE | ID: mdl-11683876

Subject(s)

Endothelial Growth Factors/metabolism; Enzyme Inhibitors/pharmacology; Indoles/pharmacology; Naphthalenes/pharmacology; Receptor Protein-Tyrosine Kinases/drug effects; Receptors, Growth Factor/drug effects; Amino Acid Sequence; Amino Acid Substitution; Animals; Base Sequence; Cloning, Molecular; Drosophila/genetics; Drug Evaluation, Preclinical/methods; Endothelial Growth Factors/genetics; Enzyme Inhibitors/chemistry; Indoles/chemistry; Molecular Sequence Data; Mutation; Naphthalenes/chemistry; Rats; Receptor Protein-Tyrosine Kinases/metabolism; Receptors, Growth Factor/metabolism; Receptors, Vascular Endothelial Growth Factor; Recombinant Proteins/genetics; Recombinant Proteins/metabolism; Sequence Homology, Amino Acid; Vascular Endothelial Growth Factor C; Vascular Endothelial Growth Factor D; Vascular Endothelial Growth Factor Receptor-3

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Collection: 01-internacional Database: MEDLINE Main subject: Endothelial Growth Factors / Receptors, Growth Factor / Receptor Protein-Tyrosine Kinases / Enzyme Inhibitors / Indoles / Naphthalenes Limits: Animals Language: En Journal: Eur J Biochem Year: 2001 Document type: Article Affiliation country: Germany Country of publication: United kingdom

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