Impaired water maze learning performance without altered dopaminergic function in mice heterozygous for the GDNF mutation.

Gerlai, R; McNamara, A; Choi-Lundberg, D L; Armanini, M; Ross, J; Powell-Braxton, L; Phillips, H S

Gerlai, R; McNamara, A; Choi-Lundberg, D L; Armanini, M; Ross, J; Powell-Braxton, L; Phillips, H S.

Affiliation

Gerlai R; Department of Neuroscience, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA. gerlai_robert@lilly.com

Eur J Neurosci ; 14(7): 1153-63, 2001 Oct.

Article in En | MEDLINE | ID: mdl-11683907

Subject(s)

Brain/metabolism; Dopamine/metabolism; Heterozygote; Learning Disabilities/genetics; Maze Learning/physiology; Mutation/physiology; Nerve Growth Factors; Nerve Tissue Proteins/deficiency; 3,4-Dihydroxyphenylacetic Acid/metabolism; Animals; Brain/physiopathology; Gene Expression/genetics; Glial Cell Line-Derived Neurotrophic Factor; Learning Disabilities/metabolism; Learning Disabilities/physiopathology; Mice; Mice, Knockout; Motor Activity/genetics; Neostriatum/metabolism; Neostriatum/physiopathology; Nerve Tissue Proteins/genetics; Neural Pathways/metabolism; Neural Pathways/physiopathology; Organ Size/genetics; Substantia Nigra/metabolism; Substantia Nigra/physiopathology

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Collection: 01-internacional Database: MEDLINE Main subject: Brain / Dopamine / Maze Learning / Heterozygote / Learning Disabilities / Mutation / Nerve Growth Factors / Nerve Tissue Proteins Type of study: Prognostic_studies Limits: Animals Language: En Journal: Eur J Neurosci Journal subject: NEUROLOGIA Year: 2001 Document type: Article Affiliation country: United States Country of publication: France

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