Targeted disruption of the zetaPKC gene results in the impairment of the NF-kappaB pathway.

Leitges, M; Sanz, L; Martin, P; Duran, A; Braun, U; García, J F; Camacho, F; Diaz-Meco, M T; Rennert, P D; Moscat, J

Leitges, M; Sanz, L; Martin, P; Duran, A; Braun, U; García, J F; Camacho, F; Diaz-Meco, M T; Rennert, P D; Moscat, J.

Affiliation

Leitges M; Max-Planck-Institut für experimentelle Endokrinologie, Feodor-Lynen-Str. 7, 30625 Hannover, Germany.

Mol Cell ; 8(4): 771-80, 2001 Oct.

Article in En | MEDLINE | ID: mdl-11684013

Subject(s)

Acetylcysteine/analogs & derivatives; Fibroblasts/physiology; Gene Targeting; I-kappa B Proteins; NF-kappa B/metabolism; Protein Kinase C/genetics; Transcription, Genetic/genetics; Acetylcysteine/pharmacology; Animals; Apoptosis/physiology; Cycloheximide/pharmacology; Cysteine Proteinase Inhibitors/pharmacology; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Enzyme Activation; Female; Fibroblasts/drug effects; Fibroblasts/enzymology; Genes, Reporter/genetics; I-kappa B Kinase; Interleukin-1/pharmacology; Lung/enzymology; Lung/physiology; Lymphocyte Subsets/metabolism; Male; Mice; Mice, Knockout; NF-KappaB Inhibitor alpha; Peyer's Patches/cytology; Peyer's Patches/metabolism; Phenotype; Phosphorylation; Protein Kinase C/metabolism; Protein Serine-Threonine Kinases/metabolism; Protein Synthesis Inhibitors/pharmacology; Recombinant Proteins/metabolism; Spleen/cytology; Spleen/metabolism; Transcription Factor RelA; Transcription Factors/metabolism; Tumor Necrosis Factor-alpha/pharmacology

Search on Google

Add to My VHL

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Acetylcysteine / Transcription, Genetic / Protein Kinase C / NF-kappa B / Gene Targeting / I-kappa B Proteins / Fibroblasts Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2001 Document type: Article Affiliation country: Germany

Search on Google

Add to My VHL

XML

PubMed Links