HSV vector-mediated gene delivery to the central nervous system.
Curr Opin Mol Ther
; 3(5): 482-90, 2001 Oct.
Article
in En
| MEDLINE
| ID: mdl-11699893
ABSTRACT
The efficient and targeted transfer of genes is the goal of gene therapy. In the central nervous system (CNS), this is challenging due in part to the exquisite anatomy of the brain. Herpes simplex virus (HSV) vectors are particularly amenable to CNS therapies as they are capable of transducing a variety of cells, have a large transgene capacity and can exist as either oncolytic or non-immunogenic vectors. The versatility of this vector platform and its potential molecular therapeutic use in two CNS disorders, Alzheimer's disease and malignant brain tumors, will be discussed.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Genetic Therapy
/
Central Nervous System Diseases
/
Simplexvirus
/
Genetic Vectors
Limits:
Animals
/
Humans
Language:
En
Journal:
Curr Opin Mol Ther
Journal subject:
BIOLOGIA MOLECULAR
/
TERAPEUTICA
Year:
2001
Document type:
Article
Affiliation country:
United States