Identification of the phosphatidylserine binding site in the C2 domain that is important for PKC alpha activation and in vivo cell localization.

Conesa-Zamora, P; Lopez-Andreo, M J; Gómez-Fernández, J C; Corbalán-García, S

Conesa-Zamora, P; Lopez-Andreo, M J; Gómez-Fernández, J C; Corbalán-García, S.

Affiliation

Conesa-Zamora P; Departamento de Bioquímica y Biología Molecular (A), Facultad de Veterinaria, Universidad de Murcia, Apartado de Correos 4021, E-30100 Murcia, Spain.

Biochemistry ; 40(46): 13898-905, 2001 Nov 20.

Article in En | MEDLINE | ID: mdl-11705379

Subject(s)

Isoenzymes/metabolism; Phosphatidylserines/metabolism; Protein Kinase C/metabolism; Alanine/genetics; Alanine/metabolism; Animals; Arginine/genetics; Arginine/metabolism; Asparagine/genetics; Asparagine/metabolism; Binding Sites/genetics; COS Cells; Calcium/metabolism; Cell Line; Cell Membrane/genetics; Cell Membrane/metabolism; Enzyme Activation/genetics; Humans; Isoenzymes/genetics; Liposomes/metabolism; Lysine/genetics; Lysine/metabolism; Micelles; Mutagenesis, Site-Directed; Phosphatidylserines/genetics; Protein Binding/genetics; Protein Kinase C/genetics; Protein Kinase C-alpha; Protein Structure, Tertiary/genetics; Protein Transport/genetics; Threonine/genetics; Threonine/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Phosphatidylserines / Protein Kinase C / Isoenzymes Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: Biochemistry Year: 2001 Document type: Article Affiliation country: Spain Country of publication: United States

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