Effects of ovarian hormones on exercise metabolism.
Curr Opin Clin Nutr Metab Care
; 4(6): 515-20, 2001 Nov.
Article
in En
| MEDLINE
| ID: mdl-11706286
ABSTRACT
Growing evidence suggests that the ovarian hormones have major effects on lipid and carbohydrate metabolism, and may also play a major role in up-stream molecular signaling mechanisms for regulating substrate metabolism. It appears that the absence of estrogen can impair glucose uptake during exercise. In contrast, progesterone not only impairs contraction-mediated glucose uptake when solely administered, but impairs glucose uptake when physiological concentrations of both estrogen and progesterone are administered. Likewise, progesterone administered to rodents for 14 days decreases glucose transporter (GLUT) 4 protein content in skeletal muscle and adipose tissue. Furthermore removing the ovaries decreases the activity of key oxidative enzymes while estrogen treatment restores the activity of these enzymes. It appears, therefore, that estrogen increases the metabolic capacity for both carbohydrate and lipid metabolism, perhaps increasing the overall metabolic flexibility of skeletal muscle. Conversely, progesterone negates both these effects, and could therefore result in a state of relative metabolic inflexibility, similar to that observed in the metabolic syndrome.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Progesterone
/
Exercise
/
Muscle, Skeletal
/
Estrogens
/
Carbohydrate Metabolism
/
Lipid Metabolism
/
Muscle Proteins
Limits:
Animals
/
Female
/
Humans
/
Male
Language:
En
Journal:
Curr Opin Clin Nutr Metab Care
Journal subject:
CIENCIAS DA NUTRICAO
/
METABOLISMO
Year:
2001
Document type:
Article
Affiliation country:
Canada