Regulated intramembrane proteolysis takes another twist.
Dev Cell
; 1(5): 590-2, 2001 Nov.
Article
in En
| MEDLINE
| ID: mdl-11709178
ABSTRACT
Rhomboid, a seven-transmembrane domain protein, has been shown genetically to potentiate EGFR signaling via the TGFalpha-like ligand Spitz. Here we discuss recently published papers that identify Rhomboid as a novel serine protease, cleaving Spitz within its transmembrane domain.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Serine Endopeptidases
/
Cell Membrane
/
Protein Processing, Post-Translational
/
Epidermal Growth Factor
/
Membrane Proteins
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Dev Cell
Journal subject:
EMBRIOLOGIA
Year:
2001
Document type:
Article
Affiliation country:
United States