Arrhythmogenic ionic remodeling: adaptive responses with maladaptive consequences.
Trends Cardiovasc Med
; 11(7): 295-301, 2001 Oct.
Article
in En
| MEDLINE
| ID: mdl-11709284
ABSTRACT
Compensatory changes in ion transport mechanisms occur in response to a variety of cardiac disease processes. Recent work has demonstrated that these adaptive responses can produce the arrhythmogenic substrate for a variety of important cardiac rhythm disorders. Two important paradigms are atrial tachycardia-induced remodeling and ionic remodeling caused by congestive heart failure. Atrial tachycardia promotes cellular Ca(2)+ loading and downregulates a variety of ion channels, particularly L-type Ca(2)+ channels, thereby promoting the occurrence and maintenance of atrial fibrillation. Congestive heart failure alters the expression and function of a variety of membrane transport processes, including several K(+)-channels and key Ca(2)+-transport systems, favoring the occurrence of arrhythmogenic afterdepolarizations. An improved understanding of the mechanisms and consequences of arrhythmogenic ionic remodeling promises to lead to novel and improved therapeutic approaches.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Arrhythmias, Cardiac
/
Tachycardia
/
Ion Transport
/
Ventricular Remodeling
/
Heart Failure
Limits:
Animals
/
Humans
Language:
En
Journal:
Trends Cardiovasc Med
Journal subject:
ANGIOLOGIA
/
CARDIOLOGIA
Year:
2001
Document type:
Article
Affiliation country:
Canada