Multiple genetic changes are associated with mammary tumorigenesis in Brca1 conditional knockout mice.

Brodie, S G; Xu, X; Qiao, W; Li, W M; Cao, L; Deng, C X

Brodie, S G; Xu, X; Qiao, W; Li, W M; Cao, L; Deng, C X.

Affiliation

Brodie SG; Genetics of Development and Disease Branch, 10/9N105, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Oncogene ; 20(51): 7514-23, 2001 Nov 08.

Article in En | MEDLINE | ID: mdl-11709723

Subject(s)

Genes, BRCA1; Mammary Neoplasms, Animal/genetics; Muscle Proteins; Animals; Antineoplastic Agents/pharmacology; Antineoplastic Agents, Hormonal/pharmacology; Blotting, Northern; Blotting, Western; CDC2 Protein Kinase/metabolism; Cell Line; Cyclin A/biosynthesis; Cyclin B/biosynthesis; Cyclin B1; Cyclin D1/metabolism; Cyclin E/biosynthesis; Cyclin-Dependent Kinase Inhibitor p16/biosynthesis; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Doxorubicin/pharmacology; Female; Gamma Rays; Genotype; Heterozygote; Immunohistochemistry; Metaphase; Mice; Mice, Knockout; Microfilament Proteins/biosynthesis; Proto-Oncogene Proteins c-myc/metabolism; Proto-Oncogene Proteins p21(ras)/biosynthesis; Receptor, ErbB-2/metabolism; Tamoxifen/pharmacology; Time Factors; Translocation, Genetic; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Mammary Neoplasms, Animal / Genes, BRCA1 / Muscle Proteins Type of study: Prognostic_studies / Risk_factors_studies Language: En Journal: Oncogene Journal subject: BIOLOGIA MOLECULAR / NEOPLASIAS Year: 2001 Document type: Article Affiliation country: United States

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