Distinct glycoprotein Ib/V/IX and integrin alpha IIbbeta 3-dependent calcium signals cooperatively regulate platelet adhesion under flow.

Nesbitt, Warwick S; Kulkarni, Suhasini; Giuliano, Simon; Goncalves, Isaac; Dopheide, Sacha M; Yap, Cindy L; Harper, Ian S; Salem, Hatem H; Jackson, Shaun P

Nesbitt, Warwick S; Kulkarni, Suhasini; Giuliano, Simon; Goncalves, Isaac; Dopheide, Sacha M; Yap, Cindy L; Harper, Ian S; Salem, Hatem H; Jackson, Shaun P.

Affiliation

Nesbitt WS; Australian Centre for Blood Diseases, Monash University, Box Hill Hospital, Box Hill, Victoria 3127, Australia.

J Biol Chem ; 277(4): 2965-72, 2002 Jan 25.

Article in En | MEDLINE | ID: mdl-11713259

Subject(s)

Blood Platelets/metabolism; Calcium/metabolism; Platelet Glycoprotein GPIIb-IIIa Complex/metabolism; Platelet Glycoprotein GPIb-IX Complex/metabolism; Cell Adhesion; Chelating Agents/pharmacology; Cytosol/metabolism; Dose-Response Relationship, Drug; Egtazic Acid/chemistry; Egtazic Acid/pharmacology; Humans; Kinetics; Mitogen-Activated Protein Kinases/metabolism; Models, Biological; Phosphatidylinositol 3-Kinases/metabolism; Protein Binding; Protein Transport; Signal Transduction; Time Factors

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Collection: 01-internacional Database: MEDLINE Main subject: Blood Platelets / Calcium / Platelet Glycoprotein GPIIb-IIIa Complex / Platelet Glycoprotein GPIb-IX Complex Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Biol Chem Year: 2002 Document type: Article Affiliation country: Australia Country of publication: United States

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